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Generic of lipitor atorvastatin in a high-dose regimens patients with coronary heart disease.[5] A similar study by the International Atherosclerosis Risk in Communities (IARCH) study, however, indicated significant adverse effects of atorvastatin plus simvastatin treatment in patients with advanced cancer.[24] A subsequent meta-analysis of trials including more than 1 million participants in patients at high risk for coronary heart disease found significant harm with atorvastatin plus simvastatin in all-cause mortality and cardiovascular mortality, which outweighed benefit with less and no higher doses of atorvastatin, particularly in patients with cardiovascular disease.[25] For patients with cardiovascular disease, the use of statins at either low or high doses for up to 5 years is associated with serious cardiovascular events and is contraindicated.[26,27] Safety concerns regarding potential adverse effects have not been substantiated by studies specifically designed to evaluate these issues. For this reason, the American Heart Association recommends against the use of any available classes atorvastatin for primary prevention of coronary heart disease.[28] In 2009, a new class of what is the generic form of atorvastatin statins for primary prevention coronary heart disease was approved by the Food and Drug Administration (FDA) to target atorvastatin-6-sulfate and atorvastatin-11-sulfate.[29,30] The new statins atorvastatin-6-sulfate and atorvastatin-11-sulfate, which are in the same lipitor vs generic atorvastatin class as atorvastatin-12-sulfate, are given at the same recommended doses by FDA. However, only atorvastatin-11-sulfate has Cheap zithromax online been approved for this indication, and thus, no information on safety and efficacy of atorvastatin-11-sulfate among patients with cardiovascular disease is available at this time. The primary mechanism of action statins to lower LDL cholesterol by inhibiting receptors and increasing HDL cholesterol by particles is through induction of bile acid synthesis. However, statins may also be induced by the direct inhibition of hepatic cholesterol synthesis or by the direct activation of lipoprotein lipase complex or apolipoprotein C (apo C) (Papas 2004). Thus, statins that reduce LDL cholesterol by inhibition of receptor function cannot be considered effective in primary prevention. addition, statins that affect other mechanisms, such as lowering HDL cholesterol (and reducing triglyceride levels) or increasing HDL concentrations can help to reduce cardiovascular events. Statins for primary prevention of CVD and cardiovascular disease do not seem to improve the outcomes of patients treated with conventional high-dose Atorvastatin 40mg $53.35 - $1.78 Per pill lipid-lowering therapies that are highly effective for patients with mild to moderate CVD and other cardiovascular risk factors (Berg 2002; Gortmaker 2004).
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