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Is lisinopril a heart medication. Heart disease and stroke are major causes of death in the UK and are expected to cause over 20,000 deaths by 2050. But there is little evidence to support the use of statins for treating heart disease, according to new work from the MRC Public Health Collaboration. It concludes that there is not enough evidence to justify statin use in the long or moderate term (lasting three years or longer). It adds that there is no evidence statins are more effective for preventing heart attacks than other types of non-pharmacological therapy. The research, published in Medical Journal of Australia, is the result a systematic review of the published papers on statins since the publication of results 2012 Cochrane review, which was the first systematic review on topic. Dr Sarah Eppworth, lead author of the study and medical research fellow at the MRC Public Health Collaboration, said they were able to address the lack of evidence "because we could look at the data". "The review identified a significant number of studies looking at the use of statins for treatment mild, moderate and severe forms of cardiovascular disease. The overall evidence base was considered sufficiently strong to allow us as a team to conduct robust and systematic review," she said. The team assessed quality and consistency of results from the studies to assess their reliability of results. "We were particularly interested in the findings and did not think we would find a large variation in the quality of data across different studies. The overall quality of evidence was quite high," Dr Eppworth explained. She added that they did not consider the results would change overall recommendations for statin use cardiovascular disease treatment. Commenting on the report's findings, Dr Anthony Shih, professor of preventive cardiology at Oxford University, said the review highlighted need to re-evaluate the evidence in context of future guidelines. "We should consider whether to replace the current low dose statin recommendations with the more detailed low dose-intensity statin recommendations," he said. added that the review highlighted there was no evidence that seemed to be a greater risk of cardiovascular deaths with statin use in people who were middle aged. "This is because a large number of studies have found no benefit for middle aged people, and the evidence in that age group is inconsistent," Dr Shih said. He added that did not think the review's results would change recommendations for elderly people, who can be treated with the old-style low dose statin rather than the more intense version. "There does not seem to be much difference in the benefit between middle-aged and older people. That was already the recommendation, and it's still recommendation that we need to use the low dose statin, because older people are more sensitive to statin side effects. "We will keep that in place [for elderly people]," he added. However, Dr Mark Pimentel, professor of medicine at Duke University School of Medicine in the US, who was not involved in the review said it would need to be replicated in a more rigorous way than was done in the review. "These results are not surprising, and this type of meta-analysis is generally done well in clinical trials. They just need to be replicated in another way than they were. But this [review] is consistent with some recent evidence that low dose statins may not actually be as superior they have long been believed to be lowering cardiovascular risk.

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